Anti–Endothelial Cell Antibodies in Vasculitis
نویسندگان
چکیده
منابع مشابه
Antiendothelial Antibodies in Scleroderma Enhance Leukocyte Adhesion
IgG autoantibodies that bind human endothelial cells (AECA) were detected by ELISA in 30 of 42 samples of sera from patients with scleroderma. Pretreatment of human umbilical vein endothelial cells with AECA-positive scleroderma sera, or IgG purified from these sera, led to a doseand timedependent increase in the ability of the cells to bind human U937 monocytic cells. Threshold-active IgG conc...
متن کاملClinical associations of serum antiendothelial cell antibodies in patients with sudden sensorineural hearing loss.
OBJECTIVES/HYPOTHESIS The role of antiendothelial cell antibodies in systemic vasculitis has been reported. The aim of the study was to define the clinical associations of serum antiendothelial cell antibodies in patients with sudden sensorineural hearing loss. STUDY DESIGN A prospective study in patients with sudden sensorineural hearing loss. METHODS Serum samples were taken from 59 conse...
متن کاملAntiendothelial cell antibodies detected by a cellular based ELISA in Kawasaki disease.
Kawasaki disease is an acute vasculitic illness of childhood associated with significant morbidity and mortality. A cellular based enzyme linked immunosorbent assay (ELISA) was used to demonstrate the presence of antiendothelial cell antibodies in sera from children with Kawasaki disease. Twenty one of 32 patients with Kawasaki disease had raised IgM antibody titres and four had raised IgG anti...
متن کاملComparison of cell-ELISA, flow cytometry and Western blotting for the detection of antiendothelial cell antibodies.
OBJECTIVE There is still great uncertainty in the detection of antiendothelial cell antibodies (AECA). The aim of our study was to compare the results obtained using different methods. METHODS Sera were obtained from 71 patients with a variety of vasculitides. Three assay methods were used: cell ELISA, flow cytometry (FACS) and Western blot (WB). RESULTS In the ELISA 12/17 patients with sys...
متن کاملPathophysiological importance of antineutrophil antibodies in vasculitis.
PURPOSE OF REVIEW We endeavour to provide a brief overview of the recent advances in understanding of how antineutrophil cytoplasmic antibodies (ANCAs) contribute to the pathophysiology of vasculitis. RECENT FINDINGS Substantial progress has been made in our understanding of the immunopathogenesis of ANCA-associated vasculitides. Compelling evidence from in-vitro studies and experimental mode...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2007
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007070767